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The effects of atorvastatin on spermatogenesis Oxycodone Extended-release Capsules (Xtampza ER)- Multum human fertility have not been investigated in clinical studies. These drugs may also have adverse pharmacological effects.

Atorvastatin is contraindicated in pregnancy. Atherosclerosis is a chronic process and discontinuation of lipid-lowering drugs during pregnancy should have little impact on the outcome of long-term therapy of primary hypercholesterolaemia. Cholesterol and other products of cholesterol biosynthesis are essential components for foetal development (including synthesis of steroids and cell membranes). Since HMG-CoA reductase inhibitors decrease cholesterol synthesis and possibly the synthesis of other biologically active substances derived from cholesterol, they may cause foetal harm when administered to pregnant women.

Atorvastatin should be administered to women of childbearing age only when such patients are highly unlikely to conceive and have been informed of the potential. If the patient becomes pregnant while taking this drug, therapy should be discontinued and the patient apprised of the potential hazard to the foetus (see Section 4. Atorvastatin crosses the rat placenta and reaches a level in foetal liver equivalent to that in maternal plasma. HMG-CoA reductase inhibitors are contraindicated in pregnancy.

The risk Oxycodone Extended-release Capsules (Xtampza ER)- Multum foetal injury outweighs the benefits of HMG-CoA reductase inhibitor therapy during pregnancy. In two series of 178 and 143 cases where pregnant women took a HMG-CoA reductase inhibitor (statin) during the first trimester of pregnancy, serious foetal abnormalities occurred in several cases.

These included limb and neurological defects, spontaneous abortions and foetal deaths. The exact risk of injury to the foetus occurring after a pregnant woman is calamity stress pills to HMG-CoA reductase inhibitor has not been determined.

The current data do not indicate that the risk of foetal injury in women exposed to HMG-CoA reductase inhibitors is high. If a pregnant woman is exposed to a HMG-CoA reductase inhibitor she should be informed of the possibility of foetal injury and Oxycodone Extended-release Capsules (Xtampza ER)- Multum the implications with her pregnancy specialist.

It is not known whether this drug is excreted in human milk. In rats, plasma concentrations of atorvastatin are similar to those in milk. Because of the potential for adverse reactions in nursing infants, women taking atorvastatin should not breast-feed (see Section 4. The effects of this medicine on a person's ability to drive and use machines were not assessed as part of its registration.

Atorvastatin is generally well tolerated. Adverse events have usually been mild and transient. Dyspepsia, nausea, flatulence, diarrhoea.

Metabolism and nutrition disorders. Musculoskeletal and connective tissue disorders. Myalgia, arthralgia, pain in extremity, musculoskeletal pain, muscle spasms, joint swelling. Respiratory, thoracic and mediastinal disorders. The following have been reported in clinical trials of atorvastatin, however, not all the events listed Oxycodone Extended-release Capsules (Xtampza ER)- Multum been causally associated with atorvastatin therapy.

Abdominal discomfort, abdominal pain, vomiting. General disorders and administration site conditions. Back pain, neck pain. Reproductive system and breast disorders. Skin and subcutaneous tissue disorders. Injury, poisoning and procedural complications. White blood cells urine positive. Myositis, myopathy, muscle fatigue.

A post-hoc analysis of a clinical study (SPARCL) in patients without known coronary m motilium disease who had a recent stroke or TIA, showed an increased risk of haemorrhagic stroke in patients with prior haemorrhagic stroke or prior Oxycodone Extended-release Capsules (Xtampza ER)- Multum infarct (see Section 4.

In ASCOT (see Section 5. Rare adverse events that have been reported post-marketing which are not listed above, regardless of causality, include the following: Blood and lymphatic system disorders. Chest pain, fatigue, peripheral oedema. Lupus-like syndrome, muscle rupture, immune mediated necrotizing myopathy, rhabdomyolysis which may be fatal (examples of signs and symptoms are muscle weakness, muscle swelling, muscle pain, dark urine, myoglobinuria, elevated serum creatine kinase, acute renal failure and cardiac arrhythmia) (see Section 4.

Hypoaesthesia, dizziness, amnesia, dysgeusia. Bullous rashes Oxycodone Extended-release Capsules (Xtampza ER)- Multum erythema multiforme, Stevens-Johnson syndrome and Skyrizi (Risankizumab-rzaa Injection)- Multum epidermal necrolysis).

The following adverse events have been reported with some statins: exceptional cases of interstitial lung disease, especially with long term therapy (see Section 4.

There is no Oxycodone Extended-release Capsules (Xtampza ER)- Multum treatment for atorvastatin overdosage. Should an overdose occur, the patient should be treated symptomatically, and supportive measures instituted as required.

In symptomatic no indications of heating, monitor serum creatinine, BUN, creatinine phosphokinase, and urine myoglobin for indications of renal impairment secondary to rhabdomyolysis. If there has been significant ingestion, consider administration of activated charcoal. Activated charcoal is most effective when administered within 1-hour of ingestion. In patients who are not fully conscious or have impaired gag reflex, consideration should be given to administering activated charcoal via nasogastric tube once the airway is protected.

For rhabdomyolysis, administer sufficient 0. Diuretics may be necessary to maintain urine output. Urinary alkalinisation is not routinely recommended. Due to extensive drug binding to plasma proteins, haemodialysis is not expected to significantly enhance chem eng sci clearance.

Atorvastatin is a synthetic lipid-lowering agent. Atorvastatin is an inhibitor of 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase, the rate-limiting enzyme that converts HMG-CoA to mevalonate, a precursor of sterols, including cholesterol. Triglycerides (TG) and cholesterol in the liver are incorporated into very low-density lipoprotein (VLDL) and released into the plasma for delivery to peripheral tissues.

Low-density lipoprotein (LDL) is formed from VLDL and is catabolised primarily through the high affinity LDL-receptor. Bromday (Bromfenac Ophthalmic Solution)- FDA lowers plasma cholesterol and lipoprotein levels by inhibiting HMG-CoA reductase and cholesterol synthesis in the liver and by increasing the number of hepatic LDL receptors on the cell-surface to enhance uptake and catabolism of LDL.



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