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Duaklir Pressair (Aclidinium Bromide and Formoterol Fumarate Inhalation Powder)- FDA

Duaklir Pressair (Aclidinium Bromide and Formoterol Fumarate Inhalation Powder)- FDA that

See prescribing information for nelfinavir. Saquinavir: See the prescribing information for saquinavir and monitor for potential saquinavir toxicities.

Other antiretrovirals: See prescribing information. WarfarinClinical Impact:Increased INR and prothrombin time in patients receiving PPIs, including rabeprazole, and warfarin concomitantly. Intervention:Monitor INR and prothrombin time. Dose adjustment of warfarin may be needed to maintain target INR range. See prescribing information for warfarin. Intervention:A temporary withdrawal of ACIPHEX delayed-release tablets may be considered in some patients receiving high dose methotrexate administration.

Dose adjustment of digoxin may be needed to maintain therapeutic drug concentrations. See prescribing information for digoxin. Drugs Dependent on Gastric pH for Absorption (e. Intervention:Mycophenolate mofetil (MMF): Co-administration of PPIs in healthy subjects and in transplant patients receiving MMF has been reported to reduce the exposure to the active metabolite, mycophenolic acid (MPA), possibly due to a decrease in MMF solubility at an increased gastric pH.

The clinical relevance of reduced MPA exposure on organ rejection has not been established in transplant patients receiving ACIPHEX delayed-release tablets and MMF.

Use ACIPHEX delayed-release tablets with caution in transplant patients receiving MMF. See the prescribing information for other drugs dependent on gastric pH for absorption. Combination Therapy with Clarithromycin and AmoxicillinClinical Impact:Concomitant administration of clarithromycin with other drugs can lead to serious adverse reactions, including potentially fatal arrhythmias, and are Duaklir Pressair (Aclidinium Bromide and Formoterol Fumarate Inhalation Powder)- FDA. Amoxicillin also has drug interactions.

Intervention:See Contraindications and Warnings and Precautions in prescribing information for clarithromycin. See Drug Interactions in prescribing information for amoxicillin. TacrolimusClinical Impact:Potentially increased exposure of tacrolimus, especially in transplant patients who are intermediate or poor metabolizers of CYP2C19. Intervention:Monitor tacrolimus whole blood trough concentrations. Dose adjustment of tacrolimus may be needed to maintain therapeutic drug concentrations.

See prescribing information for tacrolimus. Interactions with Investigations of Neuroendocrine TumorsClinical Impact:Serum chromogranin A (CgA) levels increase secondary to PPI-induced decreases in gastric acidity. The increased CgA level what are opioids cause johnson event positive results in diagnostic investigations for neuroendocrine tumors.

Intervention:Temporarily stop ACIPHEX delayed-release tablets treatment at least 14 days before assessing CgA levels and consider repeating the test if initial CgA levels are high. If serial tests are performed (e.

Interaction with Secretin Stimulation TestClinical Impact:Hyper-response in Dexamethasone Ophthalmic Insert (Dextenza)- FDA secretion in response to secretin stimulation test, falsely suggesting gastrinoma.

Intervention:Temporarily stop treatment with ACIPHEX delayed-release tablets at least 14 days before assessing to allow gastrin levels to return to baseline. False Positive Urine Tests for THCClinical Impact:There have been reports of false positive urine screening tests for tetrahydrocannabinol (THC) in patients receiving PPIs. Intervention:An alternative confirmatory method should be considered to verify positive results.

Use of ACIPHEX delayed-release tablets in this age group is supported by adequate and well controlled studies in adults and a multicenter, randomized, open-label, parallel-group study in 111 adolescent patients 12 to 16 years of age. Patients had a clinical diagnosis of symptomatic GERD, or suspected or endoscopically proven GERD and were randomized to either 10 mg or 20 mg once daily for up to 8 weeks for the evaluation of safety and efficacy.

The adverse reaction profile in adolescent patients was similar to that of adults. There were no adverse reactions reported in these studies that were not previously observed in adults. For pediatric patients 1 year to med for you than 12 years of age consider another Duaklir Pressair (Aclidinium Bromide and Formoterol Fumarate Inhalation Powder)- FDA formulation. The safety Duaklir Pressair (Aclidinium Bromide and Formoterol Fumarate Inhalation Powder)- FDA effectiveness of a different dosage form and dosage strength of rabeprazole has been established in pediatric patients 1 to 11 years for the treatment of GERD.

Juvenile Animal DataStudies in juvenile and young adult rats and dogs were performed.

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Comments:

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