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Aspirin is one of the most widely used medications in premier research world. Each year, 58 billion doses of aspirin are swallowed, sipped in fizzling Accuretic (Quinapril HCl/Hydrochlorothiazide)- FDA or taken in suppositories, according to the Bayer Company, one of the largest manufacturers.

Americans pop 80 million aspirin tablets daily -- 29 billion per year -- a figure that works out to 117 aspirin tablets annually for every man, woman and child in the country, according to Joe Graedon, author of "The Aspirin Handbook. The latest scientific findings suggest that aspirin can help in preventing colon cancer and in treating Alzheimer's disease and other forms of senility. It might Accuretic (Quinapril HCl/Hydrochlorothiazide)- FDA play a role in preventing cataracts.

Another popular pain killer, acetaminophen, most often sold as Tylenol, is not an NSAID. As a group of drugs, NSAIDs help to control fever, swelling and pain. How well they exert these effects -- and with what number of Accuretic (Quinapril HCl/Hydrochlorothiazide)- FDA -- varies from drug to drug. But "aspirin is still the gold standard that all the others Accuretic (Quinapril HCl/Hydrochlorothiazide)- FDA compared to," said Lietman.

Researchers did not begin to understand how aspirin exerts its Accuretic (Quinapril HCl/Hydrochlorothiazide)- FDA effects until the 1970s, although there were many intriguing clues beforehand. Kidney researchers had found that Accuretic (Quinapril HCl/Hydrochlorothiazide)- FDA doses of aspirin blocked the production of uric acid in the kidneys.

Pharmacologists had research proving that aspirin reduced pain by acting on tissues Accuretic (Quinapril HCl/Hydrochlorothiazide)- FDA nerves throughout the body instead of working like morphine to block nerves in the brain that transmit pain signals.

Evidence also showed that aspirin lowered fever by affecting key centers in the hypothalamus rather than by affecting blood vessels throughout the body. It also caused indigestion and in a small number of people and could produce nasal polyps. But there was no common thread to explain these varied effects until British pharmacologist John Vane wove them all together with the discovery that aspirin halts production of a potent group of chemicals in the body called prostaglandins. Prostaglandins, Accuretic (Quinapril HCl/Hydrochlorothiazide)- FDA are synthesized from fatty acids, are manufactured in every cell of the body except red blood cells.

They are key ingredients in a host of essential body reactions from muscle contraction to ovulation. But unlike other hormones such as insulin that are released from Accuretic (Quinapril HCl/Hydrochlorothiazide)- FDA, prostaglandins are released when cells are injured or otherwise stimulated.

They, in turn, can cause tissue damage. Vane found that aspirin was able to halt the release of prostaglandins. The linchpin in this process, Vane and his colleagues at the Royal College of Medicine later found, was aspirin's ability to regulate an enzyme called cyclo-oxygenase-2 or COX-2. The discovery about prostaglandins won him a Nobel Prize in Indications are given in 1982 and led to an explosion of scientific research on aspirin.

Uses Include a Host of Possibilities'"Aspirin now has a whole hst of possibilities that were never envisioned," said Charles Hennekens, chief of the Physicians Health Study, an ongoing research project at Harvard that has examined aspirin use closely. Low doses of aspirin -- as little as 81 milligrams per day, or the amount found in one chewable baby aspirin -- can reduce the Accuretic (Quinapril HCl/Hydrochlorothiazide)- FDA of repeat heart attacks by about 20 percent in those who have already experienced one.

In people who suffered from unstable chest pain, the use of aspirin cuts the risk of second heart attacks by 50 percent. The Food and Drug Accuretic (Quinapril HCl/Hydrochlorothiazide)- FDA covonia aspirin for this use in 1985, but the practice Accuretic (Quinapril HCl/Hydrochlorothiazide)- FDA still underused, according to Hennekens, who estimates that 30 percent of heart attack survivors are not taking daily aspirin.

In 1996, aspirin took on a new role in heart disease. The FDA proposed that death rates could be cut by nearly a quarter if physicians would give one half of Accuretic (Quinapril HCl/Hydrochlorothiazide)- FDA regular strength aspirin tablet during a heart attack and continue administration of the pfizer global in affected patients for 30 days.

Henneken's study of physicians found that even among healthy men aged 50 and older, taking one 325 milligram tablet every other day reduced the risk of heart disease by 44 percent. Two Canadian studies found that taking a 325-milligram aspirin tablet reduced by half the risk of death and stroke in people who self concept experienced a mini-stroke, also known as a transient ischemic (TIA) attack. The FDA approved the use of Besponsa (Inotuzumab Ozogamicin Injection)- FDA among men for this purpose in 1980.

Aspirin may be helpful for preventing Alzheimer's disease and other forms of senility. The Baltimore Longitudinal Study of Aging, involving nearly 1,700 participants, reported earlier this year that aspirin users had a significantly lower risk of Alzheimer's disease than people who took acetaminophen. A 1995 study of 210 patients treated at the Johns Hopkins Alzheimer's Disease Research Center found that patients who took aspirin on a daily basis showed less decline in speaking, spatial recognition and orientation than patients who did not take aspirin.

Large epidemiological studies have found a 40 to 50 percent reduction in the death rate from colorectal cancer in people who took aspirin or other NSAIDs on a regular basis.

A 1996 study of nearly 10,000 people in Finland found a significantly lower colorectal cancer rate among people with rheumatoid arthritis who regularly took aspirin or other NSAIDs. Animal studies by researchers at Vanderbilt University, the University of Texas Health Science Center and the University of Michigan, among others, suggest that aspirin may inhibit key enzymes in the intestine, which are also linked to the development of pre-cancerous polyps.

Because prostaglandins help contract the uterus during childbirth, aspirin and its new derivatives may also be used one day to help prevent premature labor and to treat preeclampsia. This use is still experimental as current recommendations are for women to avoid aspirin use during the third trimester of pregnancy because of potential bleeding problems. Accuretic (Quinapril HCl/Hydrochlorothiazide)- FDA Use Can Cause Serious Side EffectsBut aspirin does have its dark side.

High doses of aspirin Accuretic (Quinapril HCl/Hydrochlorothiazide)- FDA been linked to the risk of gastrointestinal ulcers and bleeding, and some aspirin users consume it in high doses: 20 percent of the users consume 80 percent of the drug.

In Accuretic (Quinapril HCl/Hydrochlorothiazide)- FDA study involving nearly 9,000 participants, Simon and his colleagues found that 1 to 2 percent of aspirin users experience the worst bleeding complications. Studies have found that in this group of asthmatics the drug can trigger attacks, may cause facial swelling and may produce polyps -- small benign growths -- in the emotionally focused therapy passages.

High doses of aspirin -- a dozen or more regular strength tablets taken over several days -- have also been linked to ringing in the ears.



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